Well I sat down for the first act of the game (infected mode first of course) tried out both control schemes, the native psp scheme and the ps3 'plus' scheme. I have to say that it definitely feels more natural playing it with the ds3, though honestly, I do like the control scheme for the psp version and could live with it if i was actually going to be playing this on the go, it will take some getting used to. The laziness in me makes me miss the psp scheme's auto lock-on, but it would be way too easy if they had kept that for the ds3, and apparently you can't use the the plus mode control scheme for multiplayer (saddened)
All in all an decent addition to the series. I'll likely stick to r2 for multiplayer though