For Wiz you need faiz to maximize combo don't bother with blade for it's only 10% atk increase. If you had chalice and KR Joker, I suggest you use them instead for 50% combo.
Grandpa and grandson combo = 30% Def (I'll let you guess what with what.)
Our Climaxes = Den-O + Zeronos = 30% Atk
Strangers of Time and Space = Decade + Den-O = 30% Atk
Older sisters' boys = Gaim + Den-O = 30% Def
We aren't together = Den-O + Nega Den-O = 6% enemy Atk decrease
Grandpa and grandson combo = 30% Def (I'll let you guess what with what.)
Our Climaxes = Den-O + Zeronos = 30% Atk
Strangers of Time and Space = Decade + Den-O = 30% Atk
Older sisters' boys = Gaim + Den-O = 30% Def
We aren't together = Den-O + Nega Den-O = 6% enemy Atk decrease
When you encounter the big boss, don't fight it instantly, wait until your energy completely refills. Then deal the damage, so your double/triple bonus is more effective, also only use energy refills when you have the bonuses. Same applies when you encounter the double bonus PDA.