Resident Evil Villains who are still alive and out of the open (spoilers alert)
Resident Evil Villains usually have a short lifespan because they die on the game where they debut. The Longest Running villain in the franchise is Albert Wesker. That guy who wears shades in the dark appeared in at least four mainline games before his final demise inside a Volcano. Oswald Spencer may also count because fans read files about him throughout the series until Albert killed him.